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CHRNA7 蛋白

(Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].

7 results

CHRNA7 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
产品编号 ABIN7122359
 
CHRNA7 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant WB, SDS, ELISA
产品编号 ABIN7576173
 
CHRNA7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
产品编号 ABIN7508493
 
CHRNA7 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % WB, PC, Imm, SDS
产品编号 ABIN7424392
 
CHRNA7 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % WB, PC, Imm, SDS
产品编号 ABIN7413079
 
CHRNA7 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc Imm, ELISA, cryo-EM, PhD, SPR
产品编号 ABIN7597160
 
CHRNA7 宿主: 大鼠 宿主: 大肠杆菌(E. Coli) Recombinant WB, PC
产品编号 ABIN2750643
 
  • 类型 Protein
    • Protein
  • 应用范围
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Phage Display (PhD)
    • Surface Plasmon Resonance (SPR)
    • Cryogenic electron microscopy (cryo-EM)
  • 适用
    • Human
    • Rat
  • 图像
  • 抗体来源
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Wheat germ
  • 抗原表位
    • AA 23-230
    • AA 25-129
  • 标记
    • His tag
    • DYKDDDDK Tag,Strep Tag
    • GST tag
    • His tag,GST tag
    • His-IF2DI Tag
    • 非结合性
  • 蛋白类型
    • Recombinant
    • Synthetic Nanodisc
  • Format
    • Lyophilized
  • Supplier
    • antibodies-online
    • FabGennix

Latest Publications for our CHRNA7 蛋白

Chandley, Miller, Kwasigroch, Wilson, Miller: "Increased antibodies for the alpha7 subunit of the nicotinic receptor in schizophrenia." in: Schizophrenia research, Vol. 109, Issue 1-3, pp. 98-101, (2009) (PubMed).

Aliases for CHRNA7 蛋白

cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) 蛋白
neuronal acetylcholine receptor subunit alpha-7 (LOC100374356) 蛋白
cholinergic receptor, nicotinic, alpha 7 (neuronal) (chrna7) 蛋白
cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7) 蛋白
cholinergic receptor nicotinic alpha 7 subunit (Chrna7) 蛋白
cholinergic receptor, nicotinic, alpha 7 (CHRNA7) 蛋白
neuronal acetylcholine receptor subunit alpha-7 (LOC100060521) 蛋白
Acra7 蛋白
alpha7 蛋白
BTX 蛋白
CHRNA7 蛋白
CHRNA7-2 蛋白
dZ70B1.1 蛋白
NACHRA7 蛋白
nAChRa7 蛋白
NARAD 蛋白
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