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CHRNA7 产品

(Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].

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Featured CHRNA7 Categories

CHRNA7 抗体

High quality antibodies with extensive validation data.

CHRNA7 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CHRNA7 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHRNA7 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (3)
  • (7)
Cat. No. ABIN5611363
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (5)
Cat. No. ABIN736911
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (5)
Cat. No. ABIN5611362
Quantity 0.1 mg
Datasheet Datasheet

Recommended CHRNA7 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954757
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5595336
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6234667
Quantity 96 tests
Datasheet Datasheet

Recommended CHRNA7 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122359
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088463
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088462
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CHRNA7 Products

Bychkov, Kirichenko, Mikhaylova, Paramonov, Kirpichnikov, Shulepko, Lyukmanova: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." in: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).

Bychkov, Shulepko, Shlepova, Kulbatskii, Chulina, Paramonov, Baidakova, Azev, Koshelev, Kirpichnikov, Shenkarev, Lyukmanova: "SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer." in: Frontiers in cell and developmental biology, Vol. 9, pp. 739391, (2021) (PubMed).

Kulbatskii, Shenkarev, Bychkov, Loktyushov, Shulepko, Koshelev, Povarov, Popov, Peigneur, Chugunov, Kozlov, Sharonova, Efremov, Skrebitsky, Tytgat, Kirpichnikov, Lyukmanova: "Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain." in: Frontiers in cell and developmental biology, Vol. 9, pp. 662227, (2021) (PubMed).

Garg, Loring: "Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 65, Issue 9, pp. 499-512, (2017) (PubMed).

Chernyavsky, Shchepotin, Galitovkiy, Grando: "Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors." in: BMC cancer, Vol. 15, pp. 152, (2015) (PubMed).

Chernyavsky, Galitovskiy, Grando: "Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression." in: International immunopharmacology, Vol. 29, Issue 1, pp. 15-20, (2015) (PubMed).

Mogoanta, Ciurea, Pirici, Margaritescu, Simionescu, Ion, Pirici: "Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 5, pp. 475-93, (2014) (PubMed).

Chandley, Miller, Kwasigroch, Wilson, Miller: "Increased antibodies for the alpha7 subunit of the nicotinic receptor in schizophrenia." in: Schizophrenia research, Vol. 109, Issue 1-3, pp. 98-101, (2009) (PubMed).

Maouche, Polette, Jolly, Medjber, Cloëz-Tayarani, Changeux, Burlet, Terryn, Coraux, Zahm, Birembaut, Tournier: "{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1868-82, (2009) (PubMed).

Severance, Zhang, Cruz, Pakhlevaniants, Hadley, Amin, Wecker, Reed, Cuevas: "The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels." in: Molecular pharmacology, Vol. 66, Issue 3, pp. 420-9, (2004) (PubMed).

Synonyms and alternative names related to CHRNA7

cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100374356), cholinergic receptor, nicotinic, alpha 7 (neuronal) (chrna7), cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7), cholinergic receptor nicotinic alpha 7 subunit (Chrna7), cholinergic receptor, nicotinic, alpha 7 (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100060521), Acra7, alpha7, BTX, CHRNA7, CHRNA7-2, dZ70B1.1, NACHRA7, nAChRa7, NARAD

Protein level used designations for CHRNA7

  • a7 nicotinic acetylcholine receptor
  • alpha 7 neuronal nicotinic acetylcholine receptor
  • alpha-7 nicotinic cholinergic receptor subunit
  • cholinergic receptor, nicotinic, alpha polypeptide 7
  • neuronal acetylcholine receptor protein, alpha-7 chain
  • neuronal acetylcholine receptor subunit alpha-7
  • cholinergic receptor, nicotinic, alpha 7
  • neuronal acetylcholine receptor subunit alpha-7-like
  • acetylcholine receptor alpha 7 neural
  • alpha7 nicotinic receptor
  • alpha7-nAChR
  • C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
  • C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
  • bungarotoxin alpha
  • neuronal nicotinic acetycholine receptor alpha 7
  • nicotinic receptor alpha 7 subunit
  • cholinergic receptor nicotinic alpha 7
  • alpha 7 nicotinic acetylcholine receptor
  • nicotinic acetylcholine receptor alpha7
  • CHRNA7-FAM7A fusion protein
  • cholinergic receptor, nicotinic, alpha 7 (neuronal)
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