Checkpoint with Forkhead and Ring Finger Domains 抗体
(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CHFR 抗体 (AA 141-422) (HRP) | 人 | 兔 Polyclonal |
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| CHFR 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Internal Region) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (N-Term) | 人, 小鼠, 大鼠, 豚鼠, 兔, 斑马鱼, Cow, 犬, 马 | 兔 Polyclonal |
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| CHFR 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (AA 1-653) | 人 | 小鼠 Monoclonal |
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| CHFR 抗体 | 人 | 兔 Polyclonal |
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| CHFR 抗体 (AA 141-422) (FITC) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (AA 141-422) | 人, 小鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 680) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 680) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 555) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 555) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 750) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 750) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (Biotin) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 647) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 647) | 人 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 488) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CHFR 抗体 (Alexa Fluor 488) | 人 | 兔 Polyclonal |
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Primary Antibody
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- AA 141-422
Primary Antibody
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠, 豚鼠, 兔, 斑马鱼, Cow, 犬, 马
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- N-Term
Primary Antibody
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term, AA 475-504
Primary Antibody
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 1H3-A12
- 标记
- unconjugated
- 抗体亚型
- IgG1 kappa
- 抗原表位
- AA 1-653
Primary Antibody
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- AA 141-422
Primary Antibody
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 141-422
Latest Publications for our Checkpoint with Forkhead and Ring Finger Domains 抗体
: "Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach." in: Virchows Archiv : an international journal of pathology, Vol. 460, Issue 2, pp. 163-9, (2012) (PubMed).
: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).
: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).
: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).
: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." in: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).
: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." in: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).
: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." in: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).
: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).
: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).
: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).
: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." in: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).
: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." in: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).
: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." in: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).
Aliases for Checkpoint with Forkhead and Ring Finger Domains 抗体
checkpoint with forkhead and ring finger domains (CHFR) 抗体checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) 抗体
checkpoint with forkhead and ring finger domains (Chfr) 抗体
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) 抗体
5730484M20Rik 抗体
C230082M18 抗体
CHFR 抗体
fc43f10 抗体
RNF116 抗体
rnf116 抗体
RNF196 抗体
rnf196 抗体
si:dkey-69h6.7 抗体
wu:fc43f10 抗体
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