anti-Fibronectin 1 (FN1) 抗体产品概述

Zebrafish Fibronectin 1 (FN1) interaction partners

1. the fibronectin extracellular matrix is essential for cell-surface Vangl2 expression, membrane-protrusive activity and directed migration.

2. Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.

3. Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage

4. Fn is essential for patterning interrenal organ formation, by modulating the migratory behavior of both steroidogenic interrenal and chromaffin cells.

5. Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.

6. Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.

7. reduction of fn1 function enables rescue of cardiac fusion in hand2 mutants

8. Fibronectin regulates epithelial organization during myocardial migration in zebrafish.

9. Data show that fn knockdown disrupts myogenesis, and that fn may function to regulate fiber organization and limit fast-twitch muscle fiber length.

Human Fibronectin 1 (FN1) interaction partners

1. High FN1 expression is associated with antidiastole of tuberculous pleural effusion.

2. Our results demonstrated a genetic association between the rs1250248 (FN1) SNP and endometriosis at both the genotypic and allelic level. However, although rs11674184 of GREB1 constitutes one of the most consistently associated SNPs with endometriosis in European ancestry populations, it was not found to be associated with endometriosis in this study

3. Silencing of fibronectin expression attenuated human RCC 786-O and Caki-1 cell growth and migration.

4. In this review, we present fundamental studies that have investigated the impact of fibronectin in cancer

5. This work highlights the importance of FN in skeletal development, and its potential role in the pathogenesis of a subtype of SMD.

6. Low plasma fibronectin levels are associated with the potential risk factor for anti-PF4/heparin antibody formation and developing heparin-induced thrombocytopenia.

7. HIV slow progressors with variants in the TLR and NOD2 pathways showed reduced pro-inflammatory responses compared to matched controls. Low-range plasma levels of fibronectin was observed in a LTNP harboring two FN1 variants.

8. extracellular FN was degraded during the intervertebral disc degeneration process, detrimentally affecting the function, and survival of nucleus pulposus cells

9. Tp0136 interaction with host fibronectin receptor plays an important role in spirochetal attachment to mammalian cells. [Tp0136]

10. LRP1 is required for FN turnover in response to Hsp90 inhibition by novobiocin.

11. our results suggest that the ED-A domain enhances association of the latent TGF-b1 by promoting weak direct binding to LTBP-1 and by enhancing heparin-mediated protein interactions through HepII in fibronectin.

12. The higher the concentration of fetal FN, the greater the risk of intra-amniotic infection/inflammation and preterm birth in patients with preterm labor and intact membranes.

13. In contrast to the tumor-promoting functions of fibronectin within the extracellular matrix (ECM), these data suggest that autocrine fibronectin production inhibits the metastatic potential of mesenchymal tumor cells.

14. These data support the hypothesis that fibronectin is stress-responsive and a functional HSF1 target gene.

15. The present study has shown that the pilus-1 tip protein RrgA of Streptococcus pneumoniae TIGR4 as well as its two terminal domains D3 and D4 bind to Fibronectin (FN). [RrgA]

16. Tenascin C and fibronectin are abundantly expressed in pancreatic ductal adenocarcinoma (PDAC), but they seem to have no major association with patient survival.

17. These findings suggest that pro-angiogenic remodelling of the perivascular matrix may involve TNC-induced upregulation of FN in endothelial cells.

18. ADAMTS16 impairs FN fibrillogenesis as well as fibrillin-1 and tenascin-C assembly, thus inhibiting formation of a mature extracellular matrix by cultured fibroblasts.

19. FN modulated TGF-beta superfamily signaling in endothelial cells

20. this study shows that serum fibronectin distinguishes the early stages of hepatocellular carcinoma

Mouse (Murine) Fibronectin 1 (FN1) interaction partners

1. Circulating tumor cells demonstrate enhanced migration in part through fibronectin regulation of integrin B1 and SLUG.

2. LRP1 is required for FN turnover in response to Hsp90 inhibition by novobiocin.

3. Endothelial alpha5beta1 integrins drive oxLDL-induced FN deposition and early atherogenic inflammation.

4. plasma FN exerts a critical role in safeguarding vascular organization and health, and that the two FN isoforms function in an overlapping as well as distinct manner to maintain postnatal vascular matrix integrity.

5. Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.

6. fibronectins from different sources contribute differentially to specific aspects of angiogenesis.

7. Cdc42 bypasses the need for exogenous fibronectin by stimulating cellular fibronectin deposition under the newly formed lamellipodia.

8. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.

9. we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 as the central mediators in these processes

10. FN is a fundamental component of the hematopoietic tissue and that the EIIIA exon may play a key role in modulating hematopiesis in conditions of bone marrow stress or diseases.

11. PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1

12. Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21(WAF1) in mesangial cells

13. fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities

14. The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.

15. analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation

16. scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown.

17. The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 as opposed to fibronectin.

18. Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.

19. These results suggest that the Rac1 regulation of the FN arrangement is involved in retinoic acid-induced cleft palate.

20. Fibrillar cellular fibronectin supports platelet adhesion, activation, aggregation and procoagulant activity via the interplay of a series of receptors i.e. integrins alpha5beta1 and alphaIIbbeta3, the GPIb-V-IX complex, GPVI and Toll-like receptor 4.

Cow (Bovine) Fibronectin 1 (FN1) interaction partners

1. SmCalp1 and/or SmCalp2 perform fibronectin cleavage function to impede blood clot formation around the worms in vivo.

2. present in chorionic extracellular matrix

3. plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.

4. Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.

5. Putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.

6. These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.

7. P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn

8. extracellular matrix proteins differentially regulate both phenotype and function of intact airway smooth muscle

9. The formation of ring-shaped and beaded-filament-like FN aggregates may be two early intermediate stages of FN fibrillogenesis within the fibrils away from cells, perhaps involving in the FN fibril widening/bundling.

10. may exert a specific function during blastocyst formation

Horse (Equine) Fibronectin 1 (FN1) interaction partners

1. The expression of extracellular matrix molecules fibronectin and osteopontin in vitreous and retina samples in autoimmune uveitis was investigated.

Pig (Porcine) Fibronectin 1 (FN1) interaction partners

1. The expression of the differentiation and stemness genes, FN1 and SOX9, is accompanied by cell proliferation.

2. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.

3. The relationship between hyaluronan synthesis and levels of versican, fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.

4. fibronectin has a cryptic binding site for tenascin

Xenopus laevis Fibronectin 1 (FN1) interaction partners

1. Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.