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抗Human HIPK2 抗体:
抗Mouse (Murine) HIPK2 抗体:
抗Rat (Rattus) HIPK2 抗体:
Cow (Bovine) Polyclonal HIPK2 Primary Antibody for IHC, WB - ABIN2779735
Steinmann, Schulte, Beck, Chachra, Bujnicki, Klempnauer: v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300. in Oncogene 2009
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Human Polyclonal HIPK2 Primary Antibody for EIA - ABIN358542
Guha, Chaerkady, Marimuthu, Patterson, Kashyap, Harsha, Sato, Bader, Lash, Minna, Pandey, Varmus: Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal HIPK2 Primary Antibody for ELISA, WB - ABIN565400
Esposito, Tornincasa, Chieffi, De Martino, Pierantoni, Fusco: High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. in Cancer research 2010
Human Monoclonal HIPK2 Primary Antibody for ICC, IF - ABIN2668288
Isono, Nemoto, Li, Takada, Suzuki, Katsuki, Nakagawara, Koseki: Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. in Molecular and cellular biology 2006
Hipk2 promotes PP1c-mediated Dvl (显示 DVL2 抗体) dephosphorylation via its C-terminal domain and is essential Dvl (显示 DVL2 抗体) stability.
Immunoprecipitation and pulldown experiments identified DCAF7 (显示 DCAF7 抗体) as an adaptor for the association of the adenovirus E1A (显示 BCKDHA 抗体) protein with DYRK1A (显示 DYRK1A 抗体) and HIPK2
HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 may have a role in kidney stone disease in Chinese males
HIPK2 overexpression may be a potential prognostic marker for predicting prognoses and a high risk of recurrence, particularly in patients with HPV-positive Tonsillar squamous cell carcinomas.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (显示 GABPA 抗体)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (显示 PARP1 抗体) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (显示 FBXW7 抗体)-dependent proteasomal degradation of Notch1 (显示 NOTCH1 抗体) by phosphorylating its intracellular domain (Notch1 (显示 NOTCH1 抗体)-IC) within the Cdc4 (显示 FBXW7 抗体) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (显示 HDAC5 抗体) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (显示 HDAC5 抗体)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (显示 CREB1 抗体) axis is a new arsenic-responsive CREB (显示 CREB1 抗体) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (显示 CREB1 抗体) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (显示 TGFB1 抗体)/Smad3 (显示 SMAD3 抗体) signaling pathway.
Protein levels of HIPK2 were increased in high glucose or TGF-beta (显示 TGFB1 抗体)-treated mouse glomerular mesangial cells. The HG- or TGF-beta (显示 TGFB1 抗体)-induced upregulation of p-MeCP2, NOX4 (显示 NOX4 抗体) and primary miR (显示 MLXIP 抗体)-25, but downregulation of precursor and mature miR (显示 MLXIP 抗体)-25, were attenuated by Hipk2 siRNA. The SIAH1 (显示 SIAH1 抗体)/HIPK2/MeCP2 axis played a novel role for in suppressing miR (显示 MLXIP 抗体)-25 processing and thereby upregulating NOX4 (显示 NOX4 抗体) in early diabetic nephropathy.
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (显示 KLF3 抗体) and CtBP2 (显示 CTBP2 抗体) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (显示 KLF3 抗体).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (显示 AIRE 抗体) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (显示 CEBPB 抗体) and implicate different protein kinases in the cooperation of p300 (显示 NOTCH1 抗体) with C/EBPbeta (显示 CEBPB 抗体) and C/EBPalpha (显示 CEBPA 抗体)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM