Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Logsdon, Barrey, Bassett, DeNizio, Guo, Panchenko, Dawicki-McKenna, Heun, Black: "Both tails and the centromere targeting domain of CENP-A are required for centromere establishment." in: The Journal of cell biology, Vol. 208, Issue 5, pp. 521-31, (2015) (PubMed).
Aliases for CENPA 抗体
centromere protein A (CENPA) 抗体 centromere protein A (Cenpa) 抗体 centromere protein-A (CENP-A) 抗体 centromere protein A (cenpa) 抗体 centromeric histone-3 like protein (cenp-A) 抗体 centromere-specific histone H3 CENP-A (cnp1) 抗体 cenp-A (HAN_3g422) 抗体 centromere protein A (Cenp-a) 抗体 centromere protein A L homeolog (cenpa.L) 抗体 centromere protein A (CMU_016480) 抗体 histone H3-like centromeric protein A (cenpa) 抗体 CenH3 抗体 CENP-A 抗体 Cenp-A 抗体 cenp-a 抗体 Cenp-a 抗体 CENPA 抗体 cenpx 抗体 RGD1563607 抗体 sim2 抗体