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CDT2/RAMP 蛋白

(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

5 results :

custom-made DTL 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7553752
 
custom-made DTL 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7563673
 
custom-made DTL 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB
产品编号 ABIN3134980
 
custom-made DTL 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB
产品编号 ABIN3092255
 
DTL 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN5505614
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • Cell-free protein synthesis (CFPS)
    • HEK-293 Cells
    • Escherichia coli (E. coli)
  • 抗原表位
    • AA 1-729
    • AA 1-730
  • 标记
    • His tag
    • Strep Tag
    • GST tag,His tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Aliases for CDT2/RAMP 蛋白

denticleless E3 ubiquitin protein ligase homolog (DTL) 蛋白
denticleless E3 ubiquitin protein ligase (Dtl) 蛋白
denticleless E3 ubiquitin protein ligase homolog (Dtl) 蛋白
denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) 蛋白
denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) 蛋白
2810047L02Rik 蛋白
5730564G15Rik 蛋白
cb151 蛋白
CDT2 蛋白
cdt2 蛋白
cdt2-a 蛋白
chunp6871 蛋白
DCAF2 蛋白
dcaf2 蛋白
L2DTL 蛋白
l2dtl 蛋白
RAMP 蛋白
Ramp 蛋白
ramp 蛋白
RGD1310439 蛋白
wu:fb54b02 蛋白
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