Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).
Huang, Ho, Ponzielli, Barsyte-Lovejoy, Bouffet, Picard, Hawkins, Penn: "Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells." in: Cancer research, Vol. 65, Issue 13, pp. 5607-19, (2005) (PubMed).
Chen, Ou, Chen, Choi, Shih: "R1, a novel repressor of the human monoamine oxidase A." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11552-9, (2005) (PubMed).
Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).
Aliases for CDCA7L 抗体
cell division cycle associated 7 like (CDCA7L) 抗体 cell division cycle associated 7 like L homeolog (cdca7l.L) 抗体 cell division cycle-associated 7-like protein (LOC100454683) 抗体 cell division cycle associated 7 like (Cdca7l) 抗体 BC006933 抗体 JPO2 抗体 MGC154777 抗体 R1 抗体 ram2 抗体 RAM2 抗体 RAPGEF5 抗体