CDC6 抗体
(Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6))
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008].
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Latest Publications for our CDC6 抗体
: "A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication." in: Science signaling, Vol. 6, Issue 262, pp. ra10, (2013) (PubMed).: "Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1614-27, (2004) (PubMed).
: "Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1." in: The EMBO journal, Vol. 22, Issue 3, pp. 704-12, (2003) (PubMed).
: "Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis." in: Molecular biology of the cell, Vol. 14, Issue 10, pp. 4250-9, (2003) (PubMed).
Aliases for CDC6 抗体
cell division cycle 6 (CDC6) 抗体cell division cycle 6 (Cdc6) 抗体
CDC18L 抗体
HsCDC6 抗体
HsCDC18 抗体
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