(CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008].
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Heikkila, Wheatley, Crighton, Schroder, Boakes, Kaye, Mezna, Pang, Rushbrooke, Turnbull, Olson: "Co-crystal structures of inhibitors with MRCK?, a key regulator of tumor cell invasion." in: PLoS ONE, Vol. 6, Issue 9, pp. e24825, (2011) (PubMed).
Adachi, Kano, Saido, Murata: "Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 14, Issue 3, pp. 355-69, (2009) (PubMed).