CD86 蛋白
(CD86)
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CD86 Protein (CD86) (AA 26-247) (Fc Tag) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 26-247) (His-Avi Tag) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 25-239) (His tag) | Cynomolgus | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 26-247) (Biotin,His-Avi Tag) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 24-246) (His-DYKDDDDK-Strep II Tag) | 人 | HEK-293T Cells |
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| CD86 Protein (CD86) (AA 26-247) (Fc Tag) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 19-240) (His tag) | 猕猴, Cynomolgus | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 48-244) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| CD86 Protein (CD86) (AA 26-247) (His tag,mFc Tag) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (His tag) | 兔 | 人细胞 |
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| CD86 Protein (CD86) (AA 24-245) (Fc Tag) | 小鼠 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 24-247) (His-Avi Tag,Biotin) | 人 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 19-240) (Fc Tag) | Cynomolgus | HEK-293 Cells |
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| CD86 Protein (CD86) (His tag) | 小鼠 | HEK-293 Cells |
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| CD86 Protein (CD86) (His tag) | 大鼠 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 31-247) (His tag) | 猕猴 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 1-329) (GST tag) | 人 | 小麦胚 |
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| CD86 Protein (CD86) (AA 24-244) (His tag) | 小鼠 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 24-245) (Fc Tag) | 小鼠 | HEK-293 Cells |
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| CD86 Protein (CD86) (AA 26-247) (Fc Tag,AVI tag,Biotin) | 人 | HEK-293 Cells |
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Protein
- SDS (SDS-PAGE: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- ELISA (ELISA: 有验证图片)
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- SPR (Surface Plasmon Resonance: 有验证图片)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
- 宿主
- Cynomolgus
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- Bind (Binding Studies: 有验证图片)
1 reference - 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- HPLC (High Pressure Liquid Chromatography: 有验证图片)
- 质量等级
- HPLC verified
- 宿主
- 猕猴, Cynomolgus
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 兔
- 宿主
- 人细胞
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- Cynomolgus
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 猕猴
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- Bind (Binding Studies: 有验证图片)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- Bind (Binding Studies: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
- 生物活性
- Active
Latest Publications for our CD86 蛋白
: "A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope." in: mAbs, Vol. 12, Issue 1, pp. 1725365, (2020) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma." in: Cellular immunology, Vol. 319, pp. 28-34, (2017) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma." in: Cellular immunology, Vol. 319, pp. 28-34, (2017) (PubMed).
Aliases for CD86 蛋白
CD86 molecule (CD86) 蛋白CD86 antigen (Cd86) 蛋白
CD86 molecule (Cd86) 蛋白
integrin subunit alpha 2b (Itga2b) 蛋白
B7 蛋白
B7-2 蛋白
B7.2 蛋白
B70 蛋白
Cd28l2 蛋白
CD28LG2 蛋白
CLS1 蛋白
ETC-1 蛋白
LAB72 蛋白
Ly-58 蛋白
Ly58 蛋白
MB7 蛋白
MB7-2 蛋白
TS/A-2 蛋白
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