This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].
Ahn, Song, Kim: "Adjuvant Postoperative CD40 Agonist and PD-1 Antagonist Combination Therapy in Syngeneic Tongue Cancer Mouse Model." in: Anticancer research, Vol. 40, Issue 5, pp. 2707-2713, (2020) (PubMed).
Li, Feng, Huang, Zhu, Xu, Sui, Xu, Han, Qin: "Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity." in: Scientific reports, Vol. 5, pp. 8862, (2015) (PubMed).
Zhang, Huang, Li, Sui, Wang, Liu, Xu, Yan, Song, Li: "Identification and Molecular Characterization of Microneme 5 of Eimeria acervulina." in: PLoS ONE, Vol. 9, Issue 12, pp. e115411, (2014) (PubMed).