CD276 蛋白
(CD276)
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CD276 Protein (CD276) (AA 29-245) (hFc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 27-461) (His tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 29-245) (Fc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 27-461) (hFc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 29-248) (His tag) | 小鼠 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 27-461) (Fc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 29-144) (Fc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 140-248) (Fc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 29-244) (His tag) | 小鼠 | Mammalian Cells |
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| CD276 Protein (CD276) (His tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 47-219) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| CD276 Protein (CD276) (AA 47-213) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| CD276 Protein (CD276) (AA 29-461) (His tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 47-219) | 人 | 大肠杆菌（E. Coli） |
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| CD276 Protein (CD276) (AA 29-465) (His tag) | Cynomolgus | HEK-293 Cells |
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| CD276 Protein (CD276) (DYKDDDDK-His Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (Transcript Variant 2) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 47-219) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| CD276 Protein (CD276) (AA 29-144, AA 99-330) (hFc Tag) | 人 | HEK-293 Cells |
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| CD276 Protein (CD276) (AA 99-330, AA 140-248) (hFc Tag) | 人 | HEK-293 Cells |
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Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- Greater than 95 % as determined by SDS-PAGE.
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 98 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- AcA (Activity Assay: 所列应用)
- CC (Cell Culture: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- 宿主
- Cynomolgus
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Latest Publications for our CD276 蛋白
: "B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression." in: Cell death & disease, Vol. 11, Issue 1, pp. 55, (2020) (PubMed).
: "Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276." in: ACS combinatorial science, Vol. 21, Issue 3, pp. 207-222, (2020) (PubMed).
: "Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells." in: Cancer cell, Vol. 35, Issue 2, pp. 221-237.e8, (2019) (PubMed).
: "Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 982-1000, (2019) (PubMed).
: "Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276." in: ACS combinatorial science, Vol. 21, Issue 3, pp. 207-222, (2020) (PubMed).
: "Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells." in: Cancer cell, Vol. 35, Issue 2, pp. 221-237.e8, (2019) (PubMed).
: "Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 982-1000, (2019) (PubMed).
Aliases for CD276 蛋白
CD276 molecule (CD276) 蛋白CD276 molecule S homeolog (cd276.S) 蛋白
CD276 molecule (cd276) 蛋白
CD276 antigen (Cd276) 蛋白
Cd276 molecule (Cd276) 蛋白
4Ig-B7-H3 蛋白
6030411F23Rik 蛋白
AU016588 蛋白
B7-H3 蛋白
B7h3 蛋白
B7H3 蛋白
B7RP-2 蛋白
sc:d0645 蛋白
zgc:158279 蛋白
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