CCM2 抗体
(Cerebral Cavernous Malformation 2 (CCM2))
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
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Latest Publications for our CCM2 抗体
: "Defective autophagy is a key feature of cerebral cavernous malformations." in: EMBO molecular medicine, Vol. 7, Issue 11, pp. 1403-17, (2015) (PubMed).
: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, (2005) (PubMed).
: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, (2005) (PubMed).
Aliases for CCM2 抗体
CCM2 scaffolding protein (CCM2) 抗体CCM2 scaffolding protein (Ccm2) 抗体
cerebral cavernous malformation 2 (Ccm2) 抗体
malcavernin (LOC100304744) 抗体
cerebral cavernous malformation 2 (ccm2) 抗体
BC029157 抗体
C7orf22 抗体
CCM2 抗体
malcavernin 抗体
OSM 抗体
TUF2 抗体
vtn 抗体
zgc:110233 抗体
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