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CCM2 抗体

(Cerebral Cavernous Malformation 2 (CCM2))
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].

26 results

CCM2 适用: 人 宿主: 兔 Polyclonal Biotin
产品编号 ABIN6872647
 
CCM2 适用: 人 宿主: 兔 Polyclonal Alexa Fluor 647
产品编号 ABIN6915324
 
CCM2 适用: 人 宿主: 兔 Polyclonal Alexa Fluor 680
产品编号 ABIN6904773
 
CCM2 适用: 人 宿主: 兔 Polyclonal Alexa Fluor 488
产品编号 ABIN6816331
 
CCM2 适用: 人 宿主: 兔 Polyclonal Alexa Fluor 750
产品编号 ABIN6856583
 
CCM2 适用: 人 宿主: 兔 Polyclonal Alexa Fluor 594
产品编号 ABIN6832394
 
  • 类型 Primary
    • Primary
  • 应用范围
    • Western Blotting (WB)
    • Immunofluorescence (IF)
    • ELISA
    • Immunohistochemistry (IHC)
    • Flow Cytometry (FACS)
    • Immunocytochemistry (ICC)
    • Immunofluorescence (Cultured Cells) (IF (cc))
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 适用
    • Human
    • Mouse
    • Rat
    • Cow
    • Dog
    • Guinea Pig
    • Horse
    • Rabbit
    • Zebrafish (Danio rerio)
  • 图像
  • 仅无防腐剂
  • Carrier free only
  • 抗体来源
    • Rabbit
    • Mouse
    • Goat
  • 克隆形成能力
    • Polyclonal
    • Monoclonal
  • 克隆
    • 1D1
    • 2 E4
    • 3B7
    • 5H4
  • 抗原表位
    • AA 1-444
    • AA 1-300
    • Internal Region
    • N-Term
    • AA 18-100
    • AA 2-100
  • 标记
    • 非结合性
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
    • Biotin
  • 抗体亚型
    • IgG
    • IgG1
    • IgG2a
    • IgG2b
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • Verified
  • Supplier
    • antibodies-online
    • Signalway
    • Abbexa
    • Acris
    • Aviva Systems Biology

Latest Publications for our CCM2 抗体

Marchi, Corricelli, Trapani, Bravi, Pittaro, Delle Monache, Ferroni, Patergnani, Missiroli, Goitre, Trabalzini, Rimessi, Giorgi, Zavan, Cassoni, Dejana, Retta, Pinton: "Defective autophagy is a key feature of cerebral cavernous malformations." in: EMBO molecular medicine, Vol. 7, Issue 11, pp. 1403-17, (2015) (PubMed).

Zawistowski, Stalheim, Uhlik, Abell, Ancrile, Johnson, Marchuk: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, (2005) (PubMed).

Aliases for CCM2 抗体

CCM2 scaffolding protein (CCM2) 抗体
CCM2 scaffolding protein (Ccm2) 抗体
cerebral cavernous malformation 2 (Ccm2) 抗体
malcavernin (LOC100304744) 抗体
cerebral cavernous malformation 2 (ccm2) 抗体
BC029157 抗体
C7orf22 抗体
CCM2 抗体
malcavernin 抗体
OSM 抗体
TUF2 抗体
vtn 抗体
zgc:110233 抗体
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