This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011].
Horiuchi, Kawamura, Iwanari, Ohashi, Naito, Kodama, Hamakubo: "Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 33292-302, (2013) (PubMed).
Fujita, Krause, Scheffner, Zechner, Leddy, Behrens, Sommer, Birchmeier: "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex." in: Nature cell biology, Vol. 4, Issue 3, pp. 222-31, (2002) (PubMed).
Aliases for CBLL1 抗体
Cbl proto-oncogene like 1 (CBLL1) 抗体 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog (cbll1.S) 抗体 Cbl proto-oncogene like 1 (Cbll1) 抗体 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase (cbll1) 抗体 Casitas B-lineage lymphoma-like 1 (Cbll1) 抗体 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog (cbll1.L) 抗体 AI467391 抗体 c-Cbl-like 抗体 CBLL1 抗体 cbll1 抗体 HAKAI 抗体 Hakai 抗体 hakai 抗体 RNF188 抗体 rnf188 抗体 zgc:55308 抗体