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P2Y (显示 P2RY1 抗体)(11) is transcribed during embryonic development, beginning at gastrulation, and is enriched in the developing nervous system.
a major role for P2X7R (显示 P2RX7 抗体) and P2Y11R in ATP-mediated inhibition of tumor-derived endothelial cell migration, is reported.
these results show hepatocellular carcinoma-specific expression of the P2Y11 receptor and its critical role in mediating ATP-inducing Ca2 (显示 CA2 抗体)+ signalling and regulating cancer cell migration
Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy.
Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells.
Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 (显示 PANX1 抗体) channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair.
the physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1 (显示 P2RY1 抗体)-P2Y11 receptor interaction.
vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages
P2Y11 receptor mediates interferon gamma (显示 IFNG 抗体)-induced IL-6 (显示 IL6 抗体) production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma (显示 IFNG 抗体) induced skin inflammatory conditions
P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers.
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B (显示 CPT1B 抗体)/CHKB (显示 CHKB 抗体) (rs5770917) in the Chinese population.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
G-protein coupled receptor
, P2Y purinoceptor 11-like
, P2Y purinoceptor 11
, purinergic receptor P2Y11