(Chromosome 14 Open Reading Frame 169 (C14orf169))
Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with sp7/osx by demethylating H3K4me and H3K36me, thereby inhibiting sp7/osx-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).
Eilbracht, Reichenzeller, Hergt, Schnölzer, Heid, Stöhr, Franke, Schmidt-Zachmann: "NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin." in: Molecular biology of the cell, Vol. 15, Issue 4, pp. 1816-32, (2004) (PubMed).