Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15\; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Aug 2008].
Kawano, Araki, Yoshida, Hibino, Ohnami, Makino, Kanai, Hasuwa, Yoshida, Miyado, Umezawa: "Seminal vesicle protein SVS2 is required for sperm survival in the uterus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 11, pp. 4145-50, (2014) (PubMed).