This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The encoded protein has several functions in addition to antimicrobial activity, including cell chemotaxis, immune mediator induction and inflammatory response regulation. [provided by RefSeq, Aug 2011].
Clausen, Slotved, Krogfelt, Agner: "Measurements of AMPs in stratum corneum of atopic dermatitis and healthy skin-tape stripping technique." in: Scientific reports, Vol. 8, Issue 1, pp. 1666, (2018) (PubMed).
Choi, Kim, Chi, Kwon, Chang: "Modulating the internalization of bacille Calmette-Guérin by cathelicidin in bladder cancer cells." in: Urology, Vol. 85, Issue 4, pp. 964.e7-964.e12, (2015) (PubMed).