(Caspase Recruitment Domain Family, Member 17 (CARD17))
Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Lamkanfi, Denecker, Kalai, Dhondt, Meeus, Declercq, Saelens, Vandenabeele: "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51729-38, (2004) (PubMed).
Aliases for CARD17 抗体
caspase recruitment domain family member 17 (CARD17) 抗体 INCA 抗体