The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Zou, Jha, Kim, Dryer: "The beta 1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channels." in: Molecular pharmacology, Vol. 73, Issue 2, pp. 369-78, (2008) (PubMed).
Hogan, Greg, Powers: "Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels." in: Neuroscience letters, Vol. 277, Issue 2, pp. 111-4, (2000) (PubMed).