BDNF 蛋白
(Brain-Derived Neurotrophic Factor (BDNF))
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009].
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Latest Publications for our BDNF 蛋白
: "Isolation and Identification of the High-Affinity DNA Aptamer Target to the Brain-Derived Neurotrophic Factor (BDNF)." in: ACS chemical neuroscience, Vol. 15, Issue 2, pp. 346-356, (2024) (PubMed).: "Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease." in: Theranostics, Vol. 10, Issue 15, pp. 6854-6874, (2020) (PubMed).
: "In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo." in: mAbs, Vol. 12, Issue 1, pp. 1755000, (2020) (PubMed).
: "Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5." in: The Journal of biological chemistry, Vol. 289, Issue 28, pp. 19627-36, (2014) (PubMed).
: "Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury." in: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 19, Issue 4, pp. 563-9, (2012) (PubMed).
: "Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene." in: Biochemical and biophysical research communications, Vol. 182, Issue 1, pp. 325-32, (1992) (PubMed).
: "Molecular cloning of a human gene that is a member of the nerve growth factor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 20, pp. 8060-4, (1990) (PubMed).
Aliases for BDNF 蛋白
brain derived neurotrophic factor (BDNF) 蛋白brain-derived neurotrophic factor (Bdnf) 蛋白
brain derived neurotrophic factor (Bdnf) 蛋白
brain-derived neurotrophic factor (bdnf) 蛋白
brain-derived neurotrophic factor L homeolog (bdnf.L) 蛋白
brain-derived neurotrophic factor S homeolog (bdnf.S) 蛋白
brain-derived neurotrophic factor (BDNF) 蛋白
ANON2 蛋白
BDNF 蛋白
bdnf 蛋白
bdnf-A 蛋白
BULN2 蛋白
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