BCR 抗体
(Breakpoint Cluster Region (BCR))
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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102 results
BCR
适用: 人, 小鼠, 大鼠, 小鸡, 犬, 非洲爪蟾, 斑马鱼
WB, IF, FACS, ICC, IP, PLA
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our BCR 抗体
: "Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice." in: British journal of cancer, Vol. 96, Issue 6, pp. 937-43, (2007) (PubMed).: "Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats." in: Biochimica et biophysica acta, Vol. 1772, Issue 3, pp. 307-16, (2007) (PubMed).
: "N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?" in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 11, pp. 2497-503, (2006) (PubMed).
: "Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis." in: Cancer letters, Vol. 241, Issue 2, pp. 309-19, (2006) (PubMed).
: "Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2." in: Blood, Vol. 103, Issue 9, pp. 3480-9, (2004) (PubMed).
: "p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells." in: Leukemia, Vol. 18, Issue 4, pp. 727-33, (2004) (PubMed).
: "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4685-95, (2004) (PubMed).
: "Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays." in: Experimental hematology, Vol. 32, Issue 5, pp. 476-82, (2004) (PubMed).
: "More fibrosis and thrombotic complications but similar expression patterns of markers for coagulation and inflammation in symptomatic plaques from DM2 patients." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 52, Issue 9, pp. 1141-9, (2004) (PubMed).
: "Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling." in: The EMBO journal, Vol. 20, Issue 23, pp. 6793-804, (2001) (PubMed).
Aliases for BCR 抗体
breakpoint cluster region (bcr) 抗体BCR, RhoGEF and GTPase activating protein (BCR) 抗体
BCR, RhoGEF and GTPase activating protein (bcr) 抗体
breakpoint cluster region (Bcr) 抗体
BCR, RhoGEF and GTPase activating protein (Bcr) 抗体
5133400C09Rik 抗体
AI561783 抗体
AI853148 抗体
ALL 抗体
BCR 抗体
BCR1 抗体
CML 抗体
D22S11 抗体
D22S662 抗体
mKIAA3017 抗体
PHL 抗体
si:dkey-83d9.7 抗体
zK83D9.7 抗体
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