This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].
Gehrke, Wörns, Huber, Hess, Straub, Hövelmeyer, Waisman, Kim, Schuppan, Galle, Schattenberg: "Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors." in: Journal of hepatology, Vol. 65, Issue 6, pp. 1188-1197, (2018) (PubMed).
Mitchell, Thompson, Trent, Casella: "A short domain within Bcl-3 is responsible for its lymphocyte survival activity." in: Annals of the New York Academy of Sciences, Vol. 975, pp. 132-47, (2003) (PubMed).
Elliott, Coon, Hays, Stadheim, Vincenti: "Bcl-3 is an interleukin-1-responsive gene in chondrocytes and synovial fibroblasts that activates transcription of the matrix metalloproteinase 1 gene." in: Arthritis and rheumatism, Vol. 46, Issue 12, pp. 3230-9, (2002) (PubMed).
Mitchell, Hildeman, Kedl, Teague, Schaefer, White, Zhu, Kappler, Marrack: "Immunological adjuvants promote activated T cell survival via induction of Bcl-3." in: Nature immunology, Vol. 2, Issue 5, pp. 397-402, (2001) (PubMed).