This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008].
Li, Lim, Chung, Kim, Park, Yao, Cha, Xia, Chan, Kim, Chang, Lee, Chou, Liu, Yeh, Perillo, Dunn, Kuo, Khoo, Hsu, Wu, Hsu, Yamaguchi, Huang, Sahin, Hortobagyi, Yoo, Hung: "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1." in: Cancer cell, Vol. 33, Issue 2, pp. 187-201.e10, (2018) (PubMed).
Clark, Guimarães da Costa, Bandeira Costa, Bezerra Cavalcanti, De Melo Rêgo, Beltrão: "Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions." in: European journal of histochemistry : EJH, Vol. 58, Issue 2, pp. 2334, (2014) (PubMed).