BACE1 蛋白
(Beta-secretase 1 (BACE1))
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
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Latest Publications for our BACE1 蛋白
: "Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus." in: Neural regeneration research, Vol. 15, Issue 8, pp. 1546-1553, (2020) (PubMed).: "sAβPPα is a Potent Endogenous Inhibitor of BACE1." in: Journal of Alzheimer's disease : JAD, Vol. 47, Issue 3, pp. 545-55, (2015) (PubMed).
Aliases for BACE1 蛋白
beta-secretase 1 (BACE1) 蛋白beta-site APP cleaving enzyme 1 (Bace1) 蛋白
beta-secretase 1 (Bace1) 蛋白
beta-site APP-cleaving enzyme 1 (bace1) 蛋白
ASP2 蛋白
BACE 蛋白
Bace 蛋白
BACE1 蛋白
C76936 蛋白
HSPC104 蛋白
MGC145931 蛋白
zgc:77409 蛋白
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