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Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, ICC - ABIN250638
Sarkar, Krishna, Imarisio, Saiki, OKane, Rubinsztein: A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. in Human molecular genetics 2008
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Cow (Bovine) Polyclonal MAP1LC3B Primary Antibody for EM, FACS - ABIN153145
Pyo, Nah, Kim, Lee, Heo, Lee, Jung: Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. in Autophagy 2008
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Human Polyclonal MAP1LC3B Primary Antibody for ICC, IF - ABIN388484
English, Chemali, Duron, Rondeau, Laplante, Gingras, Alexander, Leib, Norbury, Lippé, Desjardins: Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. in Nature immunology 2009
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Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, IHC (fro) - ABIN250640
Mizushima, Yamamoto, Hatano, Kobayashi, Kabeya, Suzuki, Tokuhisa, Ohsumi, Yoshimori: Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. in The Journal of cell biology 2001
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Polyclonal MAP1LC3B Primary Antibody for IHC (fro), WB - ABIN540679
Miller, Zhao, Stephenson, Cadwell, Pua, Lee, Mizushima, Iwasaki, He, Swat, Virgin: The autophagy gene ATG5 plays an essential role in B lymphocyte development. in Autophagy 2008
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Polyclonal MAP1LC3B Primary Antibody for IHC (fro), IF - ABIN540836
Aoki, Takada, Kondo, Sawaya, Aggarwal, Kondo: Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. in Molecular pharmacology 2007
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Cow (Bovine) Polyclonal MAP1LC3B Primary Antibody for ICC, IF - ABIN269556
Zheng, Terman, Hallbeck, Dehvari, Cowburn, Benedikz, Kågedal, Cedazo-Minguez, Marcusson: Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. in Autophagy 2012
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Polyclonal MAP1LC3B Primary Antibody for IHC (fro), WB - ABIN540681
Zhang, Yu, Pan, Hu, Hao, Cai, Zhu, Yu, Xie, Ma, Yuan: Small molecule regulators of autophagy identified by an image-based high-throughput screen. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, ICC - ABIN250639
Settembre, Fraldi, Jahreiss, Spampanato, Venturi, Medina, de Pablo, Tacchetti, Rubinsztein, Ballabio: A block of autophagy in lysosomal storage disorders. in Human molecular genetics 2007
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Human Polyclonal MAP1LC3B Primary Antibody for DB, ELISA - ABIN548691
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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The Calcium sensing receptor (CaSR) promotes degradation of key regulators of NLRP3 inflammasome and studied the role of Hsp70 chaperone and LC3-II to activate the NLRP3 inflammasome and produce mature IL-1b.
Results indicate the basal level of autophagy and microtubule associated protein 1 light chain 3 beta (MAP1LC3B-II) protein as potential biomarkers for docosahexaenoic acid (DHA) sensitivity in colorectal cancer (CRC) cells.
After blocking the beta-glucan receptor (CR3) or inhibiting downstream kinase (SYK) in neutrophils, the killing percent to C. albicans (regardless of endemic and non-endemic strains) and the ratio of LC3B-II/I of neutrophils were significantly decreased.
Data show that autophagy related 16 like 1 (ATG16L1) isoforms mechanistically distinguish between different microtubule associated protein 1 light chain 3 beta (LC3B) lipidation mechanisms under different cellular conditions.
using dominant negative forms of ATG proteins, we demonstrate that ATG5-12 conjugate, but not LC3-II formation, is critical for viral replication. Altogether, these findings suggest that although HCV needs the elongation complex for its replication, it has developed a mechanism to avoid canonical LC3-II accumulation at viral replication site.
High LC3B expression correlates with poor prognosis in oropharyngeal and oral cavity squamous cell carcinoma
Cav3.1 and LC3-II proteins are highly expressed in BRAFV600E compared with NRAS mutant melanomas, both in cell lines and biopsies.
Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and 3B (LC3A, LC3B) and beclin-1.
Novel genetic associations was found between LC3B (encoded by MAP1LC3B), an excellent marker for autophagic structures, and susceptibility to systemic lupus erythematosus.
Study demonstrated that the expression of LC3B was upregulated in 4nitroquinoline1oxideinduced oral carcinogenesis, accompanied with myeloidderived suppressor cells and regulatory T cells accumulation.
High p62 cytoplasmic expression on its own (p = 0.001), or in combination with low LC3B (p = 0.034), was associated with nonresponse to chemotherapy, regardless of whether or not the regiments contained paclitaxel, but there was no independent prognostic value of LC3B or p62 expression patterns for esophageal adenocarcinomas .
Here the authors present evidence for phosphorylation-driven regulation of the Nix:LC3B interaction. Isothermal titration calorimetry and NMR indicate a ~100 fold enhanced affinity of the serine 34/35-phosphorylated Nix LC3-interacting region (LIR) to LC3B and formation of a very rigid complex compared to the non-phosphorylated sequence.
The results suggest that autophagy-associated proteins LC3A, LC3B, and Beclin-1 might be potential biomarkers for subclassification, differentiation, and local metastasis in primary lung tumor.
FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation
Simultaneous high expression of LC3B (and ULK1) had a poorer survival rate in hepatocellular carcinoma patients.
LC3B and ESRRA might be a useful prognostic factor in patients with Muscle-invasive bladder cancer. The co-expression of LC3B and ESRRA might be a prognostic and therapeutic target for patients with bladder cancer.
High levels of LC3B is associated with non-small cell lung cancer.
LC3b was significantly overexpressed in malignant compared to benign prostate tissue. However, positive LC3b immunoreactivity in PCa, as a marker of increased autophagy, was independently associated with a reduced disease-specific mortality.
Our results suggested that activated Akt/mTOR-autophagy may have a role in the local T cell-mediated immunoregulatory mechanism of oral lichen planus (OLP). LC3B might be a valuable marker to monitor the disease severity of OLP.
presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer
In mouse RPE and neural retina, LC3A and LC3B were expressed at approximately equivalent levels. LC3B protein was detected in C57Bl6/J RPE and retinal lysates and was absent in the LC3BKO mouse.
At the microtubule-actin crossover junction, ATG4B detaches LC3B from melanosomal membranes by enzymatic delipidation.
Data show that interaction between miR-471-5p and autophagy member proteins regulates clearance of apoptotic germ cells via LC3-associated phagocytosis (LAP).
The crystal structure of mouse LC3B in complex with the FYCO1 LC3-interacting region (LIR) reveals the importance of the flanking region of the LIR motif.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3-II/Map1lc3 in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 and down-regulates Lc3-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3-II/Map1lc3 = microtubule-associated protein 1-light chain 3)
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro.
MREG-dependent processing links both autophagic and phagocytic processes in LC3-associated phagocytosis. MREG participates in coordinating the association of phagosomes with LC3 for content degradation with the MREG loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
p62/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia.
Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice.
LC3B plays a regulatory role in hyperoxia-induced epithelial apoptosis
The model and biochemical data provide a rationale for Atg7 dimerization: Atg8 is transferred in trans from the catalytic cysteine of one Atg7 protomer to Atg3 bound to the N-terminal domain of the opposite Atg7 protomer within the homodimer.
The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of pulmonary hypertension
a mechanism by which LC3B, through interactions with Cav-1 and Fas, can regulate apoptosis.
MAP1B is involved in the initial stages of axonogenesis, as shown by reduced axon length and increased growth cone size of cultured dorsal root ganglion neurons from MAP1B deficient mice.
Results suggest novel compensatory mechanisms for loss of LC3beta, ensuring proper FN accumulation and autophagy during fetal and neonatal life.
Data indicate that the expression of MAP1LC3A, B and autophagy-associated genes (ATG5, mTOR, Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, microtubule-associated proteins 1A/1B light chain 3B
, MAP1A/1B light chain 3 B
, autophagy-related protein LC3 B
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated protein 1 light chain 3 beta