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Ataxin 1 抗体

(Ataxin 1 (ATXN1))
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010].
Ataxin 1 抗体 Ataxin 1 抗体 Ataxin 1 抗体 (ABIN968970)

ATXN1 适用: 人 ELISA, FACS, ICC, IHC, WB 宿主: 小鼠 Monoclonal 2F5 unconjugated

Ataxin 1 抗体  (C-Term) Ataxin 1 抗体  (C-Term) Ataxin 1 抗体 (C-Term) (ABIN6260085)

ATXN1 适用: 人, 小鼠 ELISA, ICC, IF, IHC, WB 宿主: 兔 Polyclonal unconjugated

Ataxin 1 抗体 Ataxin 1 抗体 Ataxin 1 抗体 (ABIN1105458)

ATXN1 适用: 人 EIA, FACS, IF, IHC (p), WB 宿主: 小鼠 Monoclonal 2F5 unconjugated

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Popular Ataxin 1 抗体

Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity Human
Application ELISA, IHC, WB
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  • (3)
Cat. No. ABIN7144788
Quantity 100 μL
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Application ICC, IF, WB
Validations
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Quantity 100 μg
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Cat. No. ABIN1741197
Quantity 100 μg
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  • (3)
Cat. No. ABIN7249019
Quantity 200 μL
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Application ICC, IF, IHC, IP, WB
Validations
  • (3)
Cat. No. ABIN1741210
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Cat. No. ABIN1741534
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Cat. No. ABIN1741533
Quantity 100 μg
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Application ICC, IF, IHC, IP, WB
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Quantity 100 μg
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  • (3)
Cat. No. ABIN1741530
Quantity 100 μg
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Application ICC, IF, IHC, IP, WB
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  • (3)
Cat. No. ABIN1741206
Quantity 100 μg
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Application ICC, IF, WB
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Quantity 100 μg
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Application ICC, IF, IHC, IP, WB
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Quantity 100 μg
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Quantity 100 μg
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Application ICC, IF, WB
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  • (3)
Cat. No. ABIN1741537
Quantity 100 μg
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Application ICC, IF, WB
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Cat. No. ABIN1741531
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Latest Publications for our Ataxin 1 抗体

Menon, Nethisinghe, Faggiano, Vannocci, Rezaei, Pemble, Sweeney, Wood, Davis, Pastore, Giunti: "The role of interruptions in polyQ in the pathology of SCA1." in: PLoS genetics, Vol. 9, Issue 7, pp. e1003648, (2013) (PubMed).

Lim, Crespo-Barreto, Jafar-Nejad, Bowman, Richman, Hill, Orr, Zoghbi: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, (2008) (PubMed).

Krol, Krawczyk, Bosch, Aten, Hol, Reits: "Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation." in: PLoS ONE, Vol. 3, Issue 1, pp. e1503, (2008) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Burright, Davidson, Duvick, Koshy, Zoghbi, Orr: "Identification of a self-association region within the SCA1 gene product, ataxin-1." in: Human molecular genetics, Vol. 6, Issue 4, pp. 513-8, (1997) (PubMed).

Matilla, Koshy, Cummings, Isobe, Orr, Zoghbi: "The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1." in: Nature, Vol. 389, Issue 6654, pp. 974-8, (1997) (PubMed).

Quan, Janas, Popovich: "A novel CAG repeat configuration in the SCA1 gene: implications for the molecular diagnostics of spinocerebellar ataxia type 1." in: Human molecular genetics, Vol. 4, Issue 12, pp. 2411-3, (1996) (PubMed).

Banfi, Servadio, Chung, Kwiatkowski, McCall, Duvick, Shen, Roth, Orr, Zoghbi: "Identification and characterization of the gene causing type 1 spinocerebellar ataxia." in: Nature genetics, Vol. 7, Issue 4, pp. 513-20, (1994) (PubMed).

Aliases for Ataxin 1 抗体

ataxin 1 (ATXN1) 抗体
ataxin 1b (atxn1b) 抗体
ataxin 1 (Atxn1) 抗体
Ataxin 1 (Atx-1) 抗体
2900016G23Rik 抗体
ataxin 1b 抗体
ATX1 抗体
Atx1 抗体
ATXN1 抗体
atxn1 抗体
C85907 抗体
CG4547 抗体
D6S504E 抗体
dAtx-1 抗体
dAtx1 抗体
Dmel\\CG4547 抗体
ENSMUSG00000074917 抗体
Gm10786 抗体
SCA1 抗体
Sca1 抗体
sca1 抗体
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