A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008].
Wan, Zhang, Wang, Liu, Zhang, Que, Zhao: "ATAD2 is highly expressed in ovarian carcinomas and indicates poor prognosis." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 15, Issue 6, pp. 2777-83, (2014) (PubMed).
Raeder, Birkeland, Trovik, Krakstad, Shehata, Schumacher, Zack, Krohn, Werner, Moody, Wik, Stefansson, Holst, Oyan, Tamayo, Mesirov, Kalland, Akslen, Simon, Beroukhim, Salvesen: "Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers." in: PLoS ONE, Vol. 8, Issue 2, pp. e54873, (2013) (PubMed).