(ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) (ASF1A))
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008].
Sanematsu, Takami, Barman, Fukagawa, Ono, Shibahara, Nakayama: "Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells." in: The Journal of biological chemistry, Vol. 281, Issue 19, pp. 13817-27, (2006) (PubMed).
Groth, Ray-Gallet, Quivy, Lukas, Bartek, Almouzni: "Human Asf1 regulates the flow of S phase histones during replicational stress." in: Molecular cell, Vol. 17, Issue 2, pp. 301-11, (2005) (PubMed).