(Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3))
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (By similarity).
Armstrong, Healy, Halabi, Vollmer, Lark, Kemeny, Ware, Freedland: "Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer." in: Prostate cancer and prostatic diseases, Vol. 19, Issue 1, pp. 40-5, (2016) (PubMed).