(ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].
Luo, Kong, Wang, Chen, Liu, Wang, Xu, Wang, Yang: "Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration." in: Molecular medicine reports, Vol. 9, Issue 2, pp. 387-94, (2014) (PubMed).
Inoue, Randazzo: "Arf GAPs and their interacting proteins." in: Traffic (Copenhagen, Denmark), Vol. 8, Issue 11, pp. 1465-75, (2007) (PubMed).
Onodera, Hashimoto, Hashimoto, Morishige, Mazaki, Yamada, Ogawa, Adachi, Sakurai, Manabe, Wada, Matsuura, Sabe: "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities." in: The EMBO journal, Vol. 24, Issue 5, pp. 963-73, (2005) (PubMed).
Okabe, Furukawa, Kato, Hasegawa, Yamaoka, Nakamura: "Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas." in: International journal of oncology, Vol. 24, Issue 1, pp. 43-8, (2003) (PubMed).
Aliases for ASAP3 抗体
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (ASAP3) 抗体 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (asap3) 抗体 development and differentiation enhancing factor-like 1 (DDEFL1) 抗体 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (Asap3) 抗体 9430088F20Rik 抗体 ACAP4 抗体 CENTB6 抗体 DDEFL1 抗体 ddefl1 抗体 Ddefl1 抗体 Gm140 抗体 UPLC1 抗体 zgc:113885 抗体