Smooth muscle is found throughout the body where it serves a variety of functions. At a cellular level, smooth muscle can be described as an involuntary non-striated muscle. Smooth muscle consists of thick and thin filaments that are not arranged into sarcomeres, giving it a non-striated pattern. On microscopic examination, it will appear homogenous. Smooth muscle cytoplasm contains a large amount of actin and myosin. Actin and myosin act as the main proteins involved in muscle contraction.(1)
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The following targets can be used as markers for smooth muscle cells. Click on the links to see all available products.
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse vasculopathies such as thoracic aortic aneurysms and dissections as well as occlusive vascular diseases, including premature coronary artery disease and ischemic stroke.(2)
Below you will find our best-selling monoclonal ACTA2 antibodies with human and mouse reactivity. Click on a link to see available PubMed references, images and more product details.
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(1) Brant B. Hafen; Bracken Burns. Physiology, Smooth Muscle. Last Update: December 17, 2018. www.ncbi.nlm.nih.gov/books/NBK526125/
(2) Yuan SM. α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies. Braz J Cardiovasc Surg. 2015 Nov-Dec;30(6):644-9. doi: 10.5935/1678-9741.20150081. PMID: 26934405; PMCID: PMC4762557.