The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008].
Lin, Li, Huang, Lee: "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1." in: Journal of cell science, Vol. 115, Issue Pt 23, pp. 4433-45, (2002) (PubMed).
He, Dai, Yu, She, Zhao, Jiang, Chen, Zhao: "Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues." in: Gene expression, Vol. 10, Issue 5-6, pp. 231-42, (2002) (PubMed).