This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008].
Shields, Pecot, Gao, McMillan, Potts, Nagel, Purinton, Wang, Ivan, Kim, Borkowski, Khan, Rodriguez-Aguayo, Lopez-Berestein, Lea, Gazdar, Baggerly, Sood, White: "A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression." in: Molecular systems biology, Vol. 11, Issue 12, pp. 842, (2015) (PubMed).
Kim, Mendiratta, Kim, Pecot, Larsen, Zubovych, Seo, Kim, Eskiocak, Chung, McMillan, Wu, De Brabander, Komurov, Toombs, Wei, Peyton, Williams, Gazdar, Posner, Brekken, Sood, Deberardinis, Roth, Minna et al.: "Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. ..." in: Cell, Vol. 155, Issue 3, pp. 552-66, (2013) (PubMed).