TRAIL 蛋白
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| TRAIL Protein (AA 118-281, Trimer) (His-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| TRAIL Protein (AA 1-281) (GST tag) | 人 | 小麦胚 |
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| TRAIL Protein (AA 114-281) (His-DYKDDDDK-Strep II Tag) | 人 | HEK-293T Cells |
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| TRAIL Protein (AA 118-291) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 95-281) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 114-281) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 114-281) (mFc Tag) | 人 | Mammalian Cells |
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| TRAIL Protein (AA 115-281) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 1-281) (Strep Tag) | 人 | Cell-free protein synthesis (CFPS) |
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| TRAIL Protein (AA 1-291) (Strep Tag) | 小鼠 | Cell-free protein synthesis (CFPS) |
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| TRAIL Protein (AA 95-281, Extracellular Domain, N-Term, Soluble) (DYKDDDDK Tag) | 人, 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 114-281) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 1-281) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 1-291) | 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (His tag) | 人 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 118-291) (TRX tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL Protein (AA 118-291) (GST tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| TRAIL 蛋白 | 人 | 小麦胚 |
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| TRAIL Protein (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Protein
- AP (Affinity Purification: 所列应用)
- AA (Antibody Array: 所列应用)
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
1 reference - 宿主
- 人
- 宿主
- 小麦胚
- 蛋白类型
- Recombinant
Protein
- SDS (SDS-PAGE: 有验证图片)
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- PI (Protein Interaction: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293T Cells
- 蛋白类型
- Recombinant
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Tris-Bis PAGE
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 人
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- Greater than 95 % as determined by SDS-PAGE.
Protein
- Func (Functional Studies: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 质量等级
- custom-made
- 宿主
- 人
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 质量等级
- custom-made
- 宿主
- 小鼠
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 人, 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- >95 % (SDS-PAGE)
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as analyzed by SDS-PAGE and HPLC.
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- >95 % , as determined by SDS-PAGE and HPLC
- 生物活性
- Active
Protein
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- >95 % , as determined by SDS-PAGE and HPLC
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- >98 %
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- >98 %
- 生物活性
- Active
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
Protein
- CC (Cell Culture: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 98 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Latest Publications for our TRAIL 蛋白
: "Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells." in: The Journal of clinical endocrinology and metabolism, Vol. 98, Issue 6, pp. E1031-40, (2013) (PubMed).
: "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12687-90, (1996) (PubMed).
: "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12687-90, (1996) (PubMed).
Aliases for TRAIL 蛋白
TNF superfamily member 10 (TNFSF10) 蛋白tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10) 蛋白
TNF superfamily member 10 (Tnfsf10) 蛋白
tumor necrosis factor superfamily member 10 (TNFSF10) 蛋白
TNF superfamily member 10 S homeolog (tnfsf10.S) 蛋白
TNF superfamily member 10 (tnfsf10) 蛋白
A330042I21Rik 蛋白
AI448571 蛋白
Apo-2L 蛋白
APO-2L 蛋白
apo-2l 蛋白
APO2L 蛋白
apo2l 蛋白
CD253 蛋白
cd253 蛋白
Ly81 蛋白
TL2 蛋白
tl2 蛋白
tnfsf10l2 蛋白
TNLG6A 蛋白
TRAIL 蛋白
Trail 蛋白
trail 蛋白
trail1 蛋白
xtrail1 蛋白
zgc:92320 蛋白
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