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APBA1 产品

(Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

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The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008].

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APBA1 抗体

High quality antibodies with extensive validation data.

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Latest Publications for our APBA1 Products

Boyken, Grønborg, Riedel, Urlaub, Jahn, Chua: "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses." in: Neuron, Vol. 78, Issue 2, pp. 285-97, (2013) (PubMed).

Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: "Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity." in: Journal of molecular endocrinology, Vol. 38, Issue 1-2, pp. 3-17, (2007) (PubMed).

Jacobs, Williams, Francis: "Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease." in: Neuroscience, Vol. 138, Issue 2, pp. 511-22, (2006) (PubMed).

Wong, Setou, Teng, Takei, Hirokawa: "Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14500-5, (2002) (PubMed).

Biederer, Südhof: "Mints as adaptors. Direct binding to neurexins and recruitment of munc18." in: The Journal of biological chemistry, Vol. 275, Issue 51, pp. 39803-6, (2001) (PubMed).

Fisher, Pevsner, Burgoyne: "Control of fusion pore dynamics during exocytosis by Munc18." in: Science (New York, N.Y.), Vol. 291, Issue 5505, pp. 875-8, (2001) (PubMed).

Okamoto, Südhof: "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis." in: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31459-64, (1998) (PubMed).

Synonyms and alternative names related to APBA1

amyloid beta precursor protein binding family A member 1 (APBA1), amyloid beta (A4) precursor protein-binding, family A, member 1b (apba1b), ketopantoate reductase (apbA1), 2-dehydropantoate 2-reductase (apbA1), 2-dehydropantoate 2-reductase (apba1), amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1), amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1), amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1), amyloid beta precursor protein binding family A member 1 (Apba1), 6430513E09Rik, APBA1, D9S411E, Lin-10, LIN10, Mint, Mint1, MINT1, Urop11, X11, X11A, X11alpha, X11ALPHA

Protein level used designations for APBA1

  • amyloid beta (A4) precursor protein-binding, family A, member 1
  • amyloid beta A4 precursor protein-binding, family A, member 1
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
  • ketopantoate reductase
  • 2-dehydropantoate 2-reductase
  • Amyloid beta A4 precursor protein-binding family A member 1
  • amyloid beta A4 precursor protein-binding family A member 1-like
  • UROP11-110
  • adapter protein X11alpha
  • amyloid beta A4 precursor protein-binding family A member 1
  • mint-1
  • neuron-specific X11 protein
  • neuronal Munc18-1-interacting protein 1
  • amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11)
  • amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
  • adaptor protein X11alpha
  • neuronal munc18-1-interacting protein 1
  • phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
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