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Ubiquitin B 抗体

This anti-Ubiquitin B antibody is a 小鼠 单克隆 antibody detecting Ubiquitin B in WB, ELISA 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN969573
发货至: 中国

Quick Overview for Ubiquitin B 抗体 (ABIN969573)

抗原

See all Ubiquitin B (UBB) 抗体
Ubiquitin B (UBB)

适用

  • 45
  • 27
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  • 3
  • 3
  • 2
  • 2
  • 2
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  • 1
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宿主

  • 41
  • 7
小鼠

克隆类型

  • 33
  • 15
单克隆

标记

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This Ubiquitin B antibody is un-conjugated

应用范围

  • 27
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Western Blotting (WB), ELISA, Flow Cytometry (FACS)

克隆位点

3C12
  • 原理

    UBB Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human UBB expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: "Lysine acetylation targets protein complexes and co-regulates major cellular functions." in: Science (New York, N.Y.), Vol. 325, Issue 5942, pp. 834-40, (2009) (PubMed).

    Komander: "The emerging complexity of protein ubiquitination." in: Biochemical Society transactions, Vol. 37, Issue Pt 5, pp. 937-53, (2009) (PubMed).

  • 抗原

    Ubiquitin B (UBB)

    别名

    UBB

    背景

    This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

    分子量

    26 kDa

    基因ID

    7314

    UniProt

    P0CG47

    途径

    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagy, EGFR Downregulation, Ubiquitin Proteasome Pathway
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