MPL 抗体
(2 references)Quick Overview for MPL 抗体 (ABIN969542)
抗原
See all MPL 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- MPL Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human MPL expressed in E. Coli.
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亚型
- IgG2b
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anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 66-260) antibody
MPL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-175) antibodyMPL 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 1D6B7 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 311-460) antibodyMPL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) antibodyMPL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (Internal Region) antibodyMPL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB, FACS, EIA 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 401-500) antibodyMPL 适用: 人, 大鼠 FACS, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, (2009) (PubMed).
: "Genetic mutations associated with cigarette smoking in pancreatic cancer." in: Cancer research, Vol. 69, Issue 8, pp. 3681-8, (2009) (PubMed).
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: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, (2009) (PubMed).
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- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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别名
- MPL
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背景
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
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分子量
- 71.2 kDa
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基因ID
- 4352
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UniProt
- P40238
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途径
- JAK/STAT Signaling
抗原
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