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MELK 抗体 (AA 637-651)

Cited in 2+ publications. This 小鼠 单克隆 anti-MELK antibody (Clone 2G2) specifically detects MELK in ELISA, IHC, ICC 和 FACS. The antibody is reactive with 人 samples.
产品编号 ABIN969538
发货至: 中国
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Quick Overview for MELK 抗体 (AA 637-651) (ABIN969538)

抗原

See all MELK 抗体
MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

适用

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宿主

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小鼠

克隆类型

  • 60
  • 7
单克隆

标记

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This MELK antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

2G2
  • 抗原表位

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    AA 637-651

    原理

    MELK Antibody

    序列

    VYKRLVEDIL SSCKV

    纯化方法

    Purified antibody

    免疫原

    Synthesized peptide of human MELK(AA: 637-651:C-VYKRLVEDILSSCKV).

    亚型

    IgG2a
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway." in: Neuro-oncology, Vol. 13, Issue 6, pp. 622-34, (2011) (PubMed).

    Pickard, Green, Ellis, Caldas, Hedge, Mourtada-Maarabouni, Williams: "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 4, pp. R60, (2009) (PubMed).

  • 抗原

    MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

    别名

    MELK

    背景

    Maternal embryonic leucine-zipper kinase (MELK) is a key regulator of survival of stemlike GBM cells in vitro. MELK expression is increased in breast cancer tissue and this increase is also associated with poor patient survival, as predicted for a candidate oncogene.

    分子量

    74.6 kDa

    基因ID

    9833

    UniProt

    Q14680
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