TYK2 抗体
(2 references)Quick Overview for TYK2 抗体 (ABIN969448)
抗原
See all TYK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Tyk2 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of Tyk2 expressed in E. Coli.
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亚型
- IgG1
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anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibody
TYK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6H1 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibodyTYK2 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 6G12 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 750-850) antibodyTYK2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (pTyr1054), (pTyr1055) antibodyTYK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 286-372) antibodyTYK2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1-1187) antibodyTYK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (C-Term) antibodyTYK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) antibodyTYK2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1020-1069) antibodyTYK2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 401-500) antibodyTYK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
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- TYK2 (Tyrosine Kinase 2 (TYK2))
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别名
- Tyk2
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背景
- Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
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基因ID
- 7297
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UniProt
- P29597
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途径
- JAK/STAT Signaling, Hepatitis C
抗原
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