SMAD6 抗体
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北京 101111
Quick Overview for SMAD6 抗体 (ABIN969405)
抗原
See all SMAD6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SMAD6 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human SMAD6 expressed in E. Coli.
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亚型
- IgG1
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anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody
SMAD6 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 1-496) antibodySMAD6 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 285-384) antibodySMAD6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 285-384) antibodySMAD6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2A6 unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 261-495) antibodySMAD6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 285-385) antibodySMAD6 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 1-496) antibodySMAD6 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 137-182) antibodySMAD6 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (N-Term) antibodySMAD6 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) (AA 358-386) antibodySMAD6 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).
: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, (2006) (PubMed).
: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, (2006) (PubMed).
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: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).
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- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
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别名
- SMAD6
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背景
- Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
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分子量
- 53 kDa
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UniProt
- O43541
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途径
- Chromatin Binding
抗原
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