RSPO1 抗体
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北京 101111
Quick Overview for RSPO1 抗体 (ABIN969375)
抗原
See all RSPO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- R-spondin1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of R-spondin1 expressed in E. Coli.
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亚型
- IgG1
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anti-R-Spondin 1 (RSPO1) (AA 21-135) antibody
RSPO1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (AA 21-135) antibodyRSPO1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (AA 136-262) antibodyRSPO1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (AA 21-263) antibodyRSPO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (N-Term) antibodyRSPO1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (AA 21-263) antibodyRSPO1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) antibodyRSPO1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (AA 206-240) antibodyRSPO1 适用: 人 WB 宿主: 兔 Polyclonal RB54226 unconjugated
anti-R-Spondin 1 (RSPO1) (AA 21-135) antibodyRSPO1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 1 (RSPO1) (N-Term) antibodyRSPO1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).
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: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
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- RSPO1 (R-Spondin 1 (RSPO1))
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别名
- R-spondin1
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背景
- R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
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分子量
- 28.9 kDa
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基因ID
- 284654
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UniProt
- Q2MKA7
抗原
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