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RSPO1 抗体

Name: RSPO1 抗体
Brand: antibodies-online
SKU: ABIN969375
Availability: OutOfStock

This anti-RSPO1 antibody is a 小鼠单克隆 antibody detecting RSPO1 in ELISA. Suitable for 人. This Primary Antibody has been cited in 2+ publications.

Western blot analysis using R-spondin1 mouse mAb against recombinant R-spondin1 protein (1) and R-spondin1(aa21-263)-hIgGFc transfected HEK293 cell lysate(2). (RSPO1 抗体)

1 image

(2 references)

产品编号 ABIN969375

发货至: 中国

Datasheet as PDF

Quick Overview for RSPO1 抗体 (ABIN969375)

抗原

See all RSPO1 抗体

RSPO1 (R-Spondin 1 (RSPO1))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This RSPO1 antibody is un-conjugated

应用范围

ELISA

克隆位点

7A6

Discover our top product RSPO1 Primary Antibody

原理

R-spondin1 Antibody

纯化方法

Ascitic fluid

免疫原

Purified recombinant fragment of R-spondin1 expressed in E. Coli.

亚型

IgG1
anti-R-Spondin 1 (RSPO1) (AA 21-135) antibody
RSPO1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (AA 21-135) antibody
RSPO1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (AA 136-262) antibody
RSPO1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (AA 21-263) antibody
RSPO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (AA 21-263) antibody
RSPO1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) antibody
RSPO1 适用: 人, 大鼠, 小鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (AA 206-240) antibody
RSPO1 适用: 人 WB 宿主: 兔 Polyclonal RB54226 unconjugated

anti-R-Spondin 1 (RSPO1) (AA 21-135) antibody
RSPO1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (N-Term) antibody
RSPO1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-R-Spondin 1 (RSPO1) (N-Term) antibody
RSPO1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA: 1/10000

限制

仅限研究用
状态

Liquid

缓冲液

Ascitic fluid containing 0.03 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).
抗原

RSPO1 (R-Spondin 1 (RSPO1))

别名

R-spondin1

背景

R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

分子量

28.9 kDa

基因ID

284654

UniProt

Q2MKA7