PRKAA1 抗体
Quick Overview for PRKAA1 抗体 (ABIN969364)
抗原
See all PRKAA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PRKAA1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human PRKAA1 expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." in: Oncology reports, Vol. 20, Issue 6, pp. 1553-9, (2008) (PubMed).
: "Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells." in: Placenta, Vol. 29, Issue 12, pp. 1003-8, (2008) (PubMed).
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: "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." in: Oncology reports, Vol. 20, Issue 6, pp. 1553-9, (2008) (PubMed).
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- PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))
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别名
- PRKAA1
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背景
- The protein belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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分子量
- 64 kDa
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基因ID
- 5562
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UniProt
- Q13131
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途径
- AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
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