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NQO1 抗体

This anti-NQO1 antibody is a 小鼠 单克隆 antibody detecting NQO1 in WB, ELISA, IHC 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN969319
发货至: 中国

Quick Overview for NQO1 抗体 (ABIN969319)

抗原

See all NQO1 抗体
NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

适用

  • 72
  • 35
  • 34
  • 5
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  • 3
  • 3
  • 2
  • 2
  • 1

宿主

  • 68
  • 8
  • 2
  • 2
小鼠

克隆类型

  • 60
  • 20
单克隆

标记

  • 48
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This NQO1 antibody is un-conjugated

应用范围

  • 62
  • 26
  • 21
  • 17
  • 17
  • 16
  • 14
  • 14
  • 8
  • 7
  • 4
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

克隆位点

4D12
  • 原理

    NQO1 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human NQO1 expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Kansanen, Jyrkkänen, Volger, Leinonen, Kivelä, Häkkinen, Woodcock, Schopfer, Horrevoets, Ylä-Herttuala, Freeman, Levonen: "Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33233-41, (2009) (PubMed).

    Douglas, Lim, Porter, West, Pink, Ge, Wylie, Tibbits, Biggs, Curtis, Palombella, Adams, Fritz, Normant: "The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo." in: Molecular cancer therapeutics, Vol. 8, Issue 12, pp. 3369-78, (2009) (PubMed).

  • 抗原

    NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

    别名

    NQO1

    背景

    This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

    分子量

    31 kDa

    基因ID

    1728

    UniProt

    P15559
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