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MSH6 抗体

This anti-MSH6 antibody is a 小鼠 单克隆 antibody detecting MSH6 in WB, ELISA, IHC, ICC 和 FACS. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN969293
发货至: 中国

Quick Overview for MSH6 抗体 (ABIN969293)

抗原

See all MSH6 抗体
MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

适用

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宿主

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小鼠

克隆类型

  • 47
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  • 1
单克隆

标记

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This MSH6 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

3E1
  • 原理

    MSH6 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human MSH6 expressed in E. Coli.

    亚型

    IgG2a
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Grindedal, Møller, Eeles, Stormorken, Bowitz-Lothe, Landrø, Clark, Kvåle, Shanley, Maehle: "Germ-line mutations in mismatch repair genes associated with prostate cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2460-7, (2009) (PubMed).

  • 抗原

    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

    别名

    MSH6

    背景

    This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

    分子量

    160 kDa

    基因ID

    2956

    UniProt

    P52701

    途径

    DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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