MLH1 抗体 (AA 381-483)
(3 references)Quick Overview for MLH1 抗体 (AA 381-483) (ABIN969285)
抗原
See all MLH1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 381-483
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原理
- MLH1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
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亚型
- IgG1
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anti-MutL Homolog 1 (MLH1) (AA 1-756) antibody
MLH1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal M1 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 381-483) antibodyMLH1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7A7C8 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 381-483) antibodyMLH1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8C12B7 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 350-519) antibodyMLH1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 501-600) antibodyMLH1 适用: 人 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 373-735) antibodyMLH1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 452-480) antibodyMLH1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, (2008) (PubMed).
: "CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis." in: Immunology, Vol. 121, Issue 4, pp. 555-64, (2007) (PubMed).
: "A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells." in: Autophagy, Vol. 3, Issue 4, pp. 368-70, (2007) (PubMed).
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: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, (2008) (PubMed).
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- MLH1 (MutL Homolog 1 (MLH1))
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别名
- MLH1
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背景
- DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
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分子量
- 85 kDa
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基因ID
- 4292
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UniProt
- P40692
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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