KIT 抗体
Quick Overview for KIT 抗体 (ABIN969237)
抗原
See all KIT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- KIT Antibody
-
纯化方法
- Ascitic fluid
-
免疫原
- Purified recombinant fragment of human KIT expressed in E. Coli.
-
亚型
- IgG1
-
-
-
-
应用备注
- ELISA: 1/10000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
-
Clinical implications of c-Kit mutations in acute myelogenous leukemia." in: Current hematologic malignancy reports, Vol. 4, Issue 2, pp. 77-82, (2010) (PubMed).
: "C-kit-positive multipolar cells in human penile erectile tissue: expression of connexin 43 and relation to trabecular smooth muscle cells." in: Georgian medical news, Issue 180, pp. 13-9, (2010) (PubMed).
: "
-
Clinical implications of c-Kit mutations in acute myelogenous leukemia." in: Current hematologic malignancy reports, Vol. 4, Issue 2, pp. 77-82, (2010) (PubMed).
-
- KIT (Mast/stem Cell Growth Factor Receptor (KIT))
-
别名
- KIT
-
背景
- The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
-
分子量
- 145 kDa
-
基因ID
- 3815
-
UniProt
- P10721
-
途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
抗原
-