Glucagon 抗体
Quick Overview for Glucagon 抗体 (ABIN969171)
抗原
See all Glucagon (GCG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GCG Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human GCG expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle." in: International journal of molecular medicine, Vol. 22, Issue 1, pp. 127-32, (2008) (PubMed).
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: "Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle." in: International journal of molecular medicine, Vol. 22, Issue 1, pp. 127-32, (2008) (PubMed).
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- Glucagon (GCG)
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别名
- GCG
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背景
- The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
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分子量
- 21 kDa
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基因ID
- 2641
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UniProt
- P01275
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途径
- Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling
抗原
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